Borderline Personality Disorder
John G. Gunderson, MD, Professor of Psychiatry, Harvard Medical School, Boston, Massachusetts, and Director, Personality and Psychosocial Research Program, McLean Hospital, Belmont, Massachusetts
Introduction: training for disorder inconsistent; little information from previous generation; update needed with growth in knowledge; prevalence 1% to 3%; equal gender ratio
Borderline personality disorder: no clear relationship to socioeconomic status, cultural background; common in nonpsychiatric settings; 9 criteria for diagnosis; 1980 first classification system; sectors of interpersonal relationships, emotions, behavior, cognitions or identity; interpersonal sector most discriminating; modified criteria; traits of high neuroticism, low agreeableness; diagnosis can be made in adolescents; comorbidities: major depression, bipolar disorders, post-traumatic stress disorder, substance abuse; 20% remit by 1 year; 40% 2 years, 85% 8 to 10 years; 12% rate of relapse; no functional improvement with signs and symptoms remission; worse prognosis associated with chronicity; 3% to 10% suicide (young female common); heritability 55%; unified structure; genetic research validated integrity of diagnosis; interpersonal, emotional genetically determined; developmental factors essential; prediction factors: insecure attachments, hypersensitivity; family life characterized by dysfunction; parental psychiatric illness common; neglect most prevalent, clinically significant; hyperactive amygdala, underresponsive frontal cortex, elevated cortisol levels; neurohormone abnormality; high sensitivity to interpersonal relationships, aversion, misread social cues
Treatment: 1970 to 1990 >50 books documented problems; earlier treatments likely harmful; 1993 Marsha Linehan, Dialectical Behavioral Therapy; preventing repeated self-harm; coaching, combined individual and group therapy; reductions in hospital, emergency department usage; improve depression, decrease self-harm, decrease suicidality; mentalization-based treatment (Peter Fonagy, Anthony Bateman); transference focused psychotherapy (based on work of Otto Kernberg et al.); resource intensive; extended treatment; generalist model; therapist active and supportive, focus on adverse interpersonal events, recognize and accept emotions; model easily taught; now in training programs; psychopharmacologic treatments not proven useful
Summary: undefined boundaries, ineffective treatments; good prognosis for gradual recovery; responsive to psychosocial treatments; genetics insufficient to cause disorder without environmental factors; disorder stigma; Fatal Attraction led to erroneous prototype; persistent disorder; patients not easy to treat; goal for disorder inclusion in standard training
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