Chest CT for Suspected Pulmonary Embolism in Emergency Departments
Despite more use of computed tomographic pulmonary angiography (CTPA) in emergency departments (EDs) to evaluate patients for suspected pulmonary embolism (PE), PE mortality has remained stagnant. One goal of clinical decision rules is to identify patients at low risk who do not need imaging to rule out PE — decision rules include age-adjusted d-dimer (https://www.mdcalc.com/calc/10138/age-adjusted-d-dimer-venous-thromboembolism-vte), PE Rule-Out Criteria (PERC; https://www.mdcalc.com/calc/347/perc-rule-pulmonary-embolism), and YEARS Algorithm for PE (https://www.mdcalc.com/calc/4067/years-algorithm-for-pulmonary-embolism-pe). In a retrospective study in the Annals of Internal Medicine (https://doi.org/10.7326/M22-3116), European investigators assessed nearly 9000 patients who presented with suspected PE to 26 emergency departments in 6 countries and who underwent CTPAs from 2015 to 2019.
In an adjusted analysis, patients in 2019, compared with patients in 2015, had significantly more frequent use of CTPA (1112 vs 836 per 100,000 ED visits), more frequent diagnosis of PE (164 vs 138 per 100,000 ED visits), higher proportions of low-risk PEs (17% vs 9%), and lower proportions of intensive care unit admissions (21% vs 28%).
Despite decision-rule availability, CTPA use per number of patients seen in EDs has increased — raising concerns about unnecessary radiation exposure, adverse reactions, or overdiagnosis of potentially clinically irrelevant PEs (e.g., isolated single subsegmental PEs) — with much of that increase in diagnosis among low-risk patients (https://www.jwatch.org/na54341 and Ann Intern Med 2022; 175:29). Systematic education about, and structured implementation of, decision rules to guide further imaging of patients for PE might help limit CTPA use. One limitation of this study is that some of the decision rules were introduced during the 2015 to 2019 timeframe (e.g., YEARS), whereas others predated 2015.
Daniel D. Dressler, MD, MSc, MHM, FACP
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JW341321
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